The burden of motor neuron diseases in Asia, 1990-2021: temporal patterns and age-period-cohort analyses.

ABSTRACT:

Background

This study aims to characterize the temporal trends of motor neuron diseases (MNDs) burden in Asia from 1990 to 2021, estimate their age, period and cohort effects, and forecast the disease burden for the next 15 years.

Methods

Data were obtained from the Global Burden of Disease study 2021. The average annual percentage change (AAPC) of MNDs incidence, prevalence, mortality and disability-adjusted life years (DALYs) in Asia from 1990 to 2021 were estimated by joinpoint regression analysis. Age, period and cohort effects on incidence and mortality of MNDs were also evaluated by the age-period-cohort analysis. The autoregressive integrated moving average model was used to forecast age-standardized incidence, prevalence and mortality rates of Asian MNDs in 2022-2036

SUBMITTER: Shi T 

PROVIDER: S-EPMC12450676 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature