Transspinal stimulation preceding assisted step training reorganizes neuronal excitability and function of inhibitory networks in spinal cord injury: a randomized controlled trial.

ABSTRACT:

Introduction

In this pilot randomized sham-controlled clinical trial, we characterized the spinal neuronal and network excitability in human spinal cord injury (SCI) when transspinal stimulation preceded locomotor training within the same session.

Methods

Fourteen participants with chronic SCI received an average of 40 sessions with 30 Hz transspinal stimulation delivered for 30 min during standing (active: n = 4; sham: n = 5) or supine (active: n = 5) followed by 30-min of robotic assisted step training. Before and 1-2 days after completion of all training sessions, we assessed the soleus H-reflex homosynaptic depression and soleus H-reflex recruitment curve, and the amount of reciprocal and presynaptic inhibition following conditioning stimulation of t

SUBMITTER: Sayed Ahmad AM 

PROVIDER: S-EPMC12450697 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature