Aortic stenosis intricacies beyond the valve: A bidirectional Mendelian randomization study.

ABSTRACT:

Aims

Numerous observational studies have reported an association between calcific aortic valve stenosis (CAVS) and an increased risk of other cardiovascular diseases (CVDs). However, the potential causal association is uncertain.

Methods and results

A bidirectional Mendelian randomization (MR) analysis was performed to confirm the causal association between CAVS and the risk of seven common CVDs. The meta-analysis was used to estimate the combined causal effect with multiple MR results. The MR analysis indicated that genetically predicted CAVS is associated with the increased risk of heart failure (odds ratio [OR] = 1.064; 95% confidence interval [CI] [1.008, 1.123]; P = 0.025), large-artery stroke (OR = 1.256; 95% CI [1.112, 1.418]; P < 0.001), cardioembolic stroke (OR = 1.

SUBMITTER: Cai D 

PROVIDER: S-EPMC12450768 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature