Proteins associated with rehospitalization, mortality and diuretic resistance in acutely decompensated heart failure.

ABSTRACT:

Aims

Most proteomic analyses in patients with heart failure (HF) focus on the stable ambulatory setting; pathways that drive acute decompensated heart failure (ADHF) are largely uncharacterized. We aimed to examine the associations of cardiometabolic proteins with HF rehospitalization, mortality and diuretic response in patients with ADHF.

Methods

The Mechanisms of Diuretic Resistance Cohort comprised patients hospitalized for ADHF at Yale New Haven Hospital from 2015 to 2020. We quantified 369 serum proteins and evaluated their associations with rehospitalization, mortality or diuretic response, using individual and combined biomarkers. Models adjusted for sociodemographic/lifestyle factors, comorbidities and clinical factors. For individual biomarker models, significant pr

SUBMITTER: Hubbell KT 

PROVIDER: S-EPMC12450773 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature