Prognostic impact of peak oxygen consumption in heart failure: A systematic review and meta-analysis.

ABSTRACT:

Background and aims

Heart failure (HF) is a multifactorial disease for which peak oxygen uptake (VO₂peak) may potentially be a prognostic marker of adverse clinical outcomes. This systematic review and meta-analysis aimed to assess published data on the prognostic impact of VO₂peak in HF.

Methods

A literature search of observational studies was conducted through PubMed, Scopus, Web of Science and Cochrane Library from inception until January 2025. A meta-analysis was conducted using the random-effects inverse-variance model through hazard ratios (HRs). Increased heterogeneity among studies was evaluated through meta-regressions and publication bias via Egger's test.

Results

Sixty-four studies were included in this systematic review and meta-analy

SUBMITTER: Prokopidis K 

PROVIDER: S-EPMC12450781 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature