Epicardial, visceral and subcutaneous adipose tissue in heart failure with preserved ejection fraction.

ABSTRACT:

Aims

Obesity is common in patients with heart failure with preserved ejection fraction (HFpEF), and adipose tissue (AT) plays a key role in its pathophysiology. We examined the distribution and association of visceral AT (VAT), subcutaneous AT (SAT) and epicardial AT (EAT) in HFpEF using multimodality imaging.

Methods

Heart failure patients with left ventricular ejection fraction >40% were prospectively enrolled. All patients underwent cardiac magnetic resonance (CMR) imaging and total body computed tomography (CT). EAT was measured on CMR, and VAT, SAT and waist circumference (WC) were measured on CT. Linear regression analysis was used to assess associations between EAT and other AT depots.

Results

In total, 68 patients were included. Mean age was 73 ± 8 years; 34 (

SUBMITTER: Lobeek M 

PROVIDER: S-EPMC12450799 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature