Efficacy of ambulatory intravenous diuresis for chronic heart failure patients: Insights from the DEA-HF trial.

ABSTRACT:

Aims

Oral diuretic treatment has limited efficacy in managing chronic heart failure (HF) patients. Novel strategies are needed to manage patients with refractory congestion despite optimal HF therapy and high-dose oral diuretic treatment. In the present study, we prospectively quantified the efficacy and safety of an ambulatory, weekly, high-dose parenteral diuresis strategy.

Methods and results

Data from the prospective, randomized, cross-over controlled study for comparisons of diuresis efficacy in HF patients (DEA-HF) were analysed. Chronic HF patients with congestion despite guideline-directed medical therapy were enrolled to receive three high-intensity diuretic regimens, once a week, in a randomized order: intravenous (IV) furosemide 250 mg; IV furosemide 250 mg + oral

SUBMITTER: Gruber A 

PROVIDER: S-EPMC12450800 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature