Patient-specific modifiers of survival benefit in cardiac resynchronization therapy - A multicentre interaction analysis.

ABSTRACT:

Background

Cardiac resynchronization therapy (CRT) is a key intervention for patients with heart failure. The choice between a CRT with defibrillator therapy (CRT-D) and a CRT with pacemaker (CRT-P) is influenced by individual clinical characteristics. This study explores the interaction between these clinical variables and the benefit of CRT-D versus CRT-P on all-cause mortality.

Methods

All patients who underwent CRT implantation in three European centres were included in a multicentre, retrospective registry. The impact of clinical variables on all-cause mortality was analysed using interaction tests within multivariable Cox proportional hazard models. Significant interactions were explored to assess how patient characteristics modify the effect of CRT-D compared with CRT

SUBMITTER: Vandenberk B 

PROVIDER: S-EPMC12450839 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature