The association of artificial sweeteners intake and risk of cancer: an umbrella meta-analysis.

ABSTRACT:

Background

Previous meta-analyses exploring the relationship between artificial sweetener consumption and cancer risk have shown inconsistent results. To address these discrepancies, we conducted an umbrella review of systematic reviews and meta-analyses of observational studies.

Methods

We systematically searched PubMed, Scopus, and Web of Science up to January 2025. Pooled relative risks (RRs) and 95% confidence intervals (CIs) were recalculated using a random-effects model. Subgroup and sensitivity analyses assessed the robustness of findings.

Results

Ten meta-analyses comprising 35 datasets were included. Based on the AMSTAR 2 tool, three reviews were rated as high quality, two as moderate, and five as low. Overall, artificial sweetener intake was not significantl

SUBMITTER: Abu-Zaid A 

PROVIDER: S-EPMC12450865 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature