Occupational exposure and its mechanistic link to allergic asthma and lung function decline; a data-driven approach coupled to mining of adverse outcome pathway signatures.

ABSTRACT: Within occupational epidemiology, the establishment of associations between chemical exposures and health outcome, in particular of individual chemicals present in the exposome, is difficult. Epidemiological studies are valuable but may be prone to confounders, or lack detailed exposure characterisation. Rodent studies may suffer from interspecies differences in comparison to humans. Here, we explore if a data driven approach can leverage human relevant mechanistic information to inform presumed associations between chemical exposures and two common respiratory disorders: lung function decline (LFD) and allergic asthma (AA). Using public toxicogenomics datasets, we identified Gene Ontology Bioprocesses (GO BPs) enriched in human respiratory cells, exposed in vitro to either diesel u

SUBMITTER: Stierum R 

PROVIDER: S-EPMC12450882 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature