Swine influenza-modified pulmonary microbiota.

ABSTRACT: Influenza A virus (IAV) remains a major health concern in both humans and animals, with pigs serving as key reservoirs for generating novel reassortant viruses with pandemic potential. Respiratory microbiome alterations during infection may facilitate secondary bacterial complications. This study investigates the lung microbiota of pigs naturally infected with IAV across different regions in Spain, using Oxford Nanopore Technologies (ONT) long-read 16S rRNA sequencing to characterize associated bacterial communities. Our results show a higher bacterial genus diversity in IAV-infected animals compared to healthy controls, with significant differences in both presence and relative abundance of bacterial taxa. Infected lungs exhibited increased proportions of potential pathogens, particularly

SUBMITTER: Arranz-Herrero J 

PROVIDER: S-EPMC12450909 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature