Navigating an evolving microbial landscape: emerging antimicrobial resistance trends and precision stewardship in Tianjin tertiary hospitals (2021-2023).

ABSTRACT:

Objective

To evaluate microbial distribution and antimicrobial resistance (AMR) patterns in clinical isolates from 13 tertiary hospitals and one secondary hospital in Tianjin (2021-2023) to inform precision-driven antimicrobial stewardship and infection control interventions.

Methods

In this retrospective, multicenter study, we collected routine diagnostic specimens-including sputum, fecal samples, secretions, blood, and drainage fluids. Data were processed per standardized protocols (CARSS, CHINET) and interpreted using current CLSI-M100 breakpoints. Statistical analyses were performed with SPSS 20.0 (significance set at two-tailed P < 0.05).

Results

Sputum specimens increased from 39.1% to 43.0%, while urine samples and secretions declined. Klebsiella pneu

SUBMITTER: Wan YL 

PROVIDER: S-EPMC12450913 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature