Selenomethionine alleviates LPS-induced septic kidney injury by regulating mitochondrial dynamics changes.

ABSTRACT:

Background

Acute kidney injury (AKI) is a prevalent complication of sepsis, where the inflammatory response plays a crucial role. Selenium exhibits anti-inflammatory and antioxidant properties, but its impact on sepsis-induced AKI remains unclear.

Methods and results

In this study, we used a lipopolysaccharide (LPS)-induced murine model of sepsis-associated acute kidney injury (SA-AKI) in male C57BL/6 mice (8-12 weeks old) to investigate the protective mechanisms of selenomethionine (SeMet). Mice received weekly oral administration of SeMet (0.375 mg/kg) commencing 1 week prior to AKI induction. Our results demonstrated that SeMet treatment significantly attenuated the inflammatory response, reduced oxidative stress, and ameliorated renal pathological damage compared to sali

SUBMITTER: Zhou X 

PROVIDER: S-EPMC12450938 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature