Association Between the Combined Effects and Joint Trajectories of Depression and Frailty and the Risk of Digestive Diseases: A Longitudinal Study.

ABSTRACT:

Background and aims

Digestive diseases, including gastrointestinal and liver disorders, are prevalent and contribute significantly to morbidity, healthcare costs, and reduced quality of life, particularly among middle-aged adults. Frailty, characterized by reduced physiological reserve, and depression, a common psychological disorder, have both been linked to an increased risk of these conditions. However, the combined impact of frailty and depression on digestive diseases remains poorly understood. This study aimed to examine the combined effects and joint trajectories of frailty and depression on the risk of digestive diseases in middle-aged adults and explore potential mechanisms of their interaction.

Methods

We conducted a prospective cohort study using data from the Chi

SUBMITTER: Fan X 

PROVIDER: S-EPMC12451021 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature