Evaluating the Causal Effects of Serum and Cerebrospinal Fluid Metabolites on Cerebral Palsy: A Whole-Metabolome Mendelian Randomization Study.

ABSTRACT:

Purpose

This study aimed to investigate the causal relationships between serum and cerebrospinal fluid (CSF) metabolites and cerebral palsy (CP) risk, leveraging genetic insights to identify potential biomarkers and metabolic pathways implicated in CP pathogenesis.

Method

A two-sample Mendelian randomization (MR) approach was employed to analyze 1400 serum metabolites and 338 CSF metabolites. Genetic variants associated with metabolite levels were used as instrumental variables (IVs) to infer causal effects on CP risk.

Findings serum metabolites

Sixty-nine metabolites showed significant associations with CP risk, including 1-(1-enyl-stearoyl)-2-linoleoyl-GPE (protective effect: odd ratio [OR] = 0.84, p = 0.001) and 1,2-dipalmitoyl-GPC (risk effect: OR = 1.12, p = 0.00

SUBMITTER: Dai Y 

PROVIDER: S-EPMC12451031 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature