Exploring the Link Between Inflammatory Biomarkers (SII, SIRI, PLR, NLR, LMR) and Migraine in Young and Early Middle-Aged US Adults: Evidence From NHANES 1999-2004 and Machine Learning Models.

ABSTRACT:

Background

Migraines are a prevalent neurological condition that significantly impacts quality of life, but the underlying pathophysiology remains unclear. This study aims to explore the relationship between inflammatory biomarkers and migraine prevalence in young and early middle-aged Americans. The inflammatory biomarkers considered include the Systemic Immune-Inflammation Index (SII), Systemic Inflammatory Response Index (SIRI), Platelet-to-Lymphocyte Ratio (PLR), Neutrophil-to-Lymphocyte Ratio (NLR), and Lymphocyte-to-Monocyte Ratio (LMR).

Methods

Data from the National Health and Nutrition Examination Survey (NHANES) 1999-2004 were utilized for this investigation. Subgroup analysis, smooth curve fitting, and multivariable logistic regression were employed to evaluate as

SUBMITTER: Ha G 

PROVIDER: S-EPMC12451049 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature