Microstructural Hippocampal Alterations in Alzheimer's Disease: A Systematic Review and Meta-Analysis of Diffusion Kurtosis Imaging.

ABSTRACT:

Background

The hippocampus is highly vulnerable in Alzheimer's disease (AD), with early microstructural changes potentially detectable via diffusion kurtosis imaging (DKI). Previous studies report promising DKI findings in AD, necessitating systematic evaluation. To compare hippocampal DKI metrics, particularly mean kurtosis (MK), between AD patients and healthy controls (HCs) and explore factors influencing these differences.

Methods

Following PRISMA guidelines, PubMed, Scopus, Web of Science, and Embase were searched until November 2024. Two reviewers independently extracted hippocampal MK values. Risk of bias was evaluated using the Newcastle-Ottawa Scale. Meta-analysis employed random-effects models (STATA v17). Subgroup analyses (sex, age, magnetic resonance imaging [MR

SUBMITTER: Ahmadzadeh AM 

PROVIDER: S-EPMC12451067 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature