Concerted Actions of FoxO1 and PPARα in Hepatic Gene Expression and Metabolic Adaptation.

ABSTRACT: Several transcription factors regulate the fasting response in liver. They include FoxO1 and FoxO3, CREB, C/EBP α/β, glucocorticoid receptor (GR), peroxisome proliferator-activated receptor-α (PPARα), FoxA2, hepatocyte nuclear factor-α (HNF4α), and others. Genome-wide chromatin occupancy studies revealed an unexpected overlap of FoxO1 and PPARα DNA binding sites at active intergenic and intron enhancers, yet their functional significance remains unknown. To address this gap in knowledge, we conducted molecular interaction analyses of these transcription factors and generated combined hepatocyte-specific ablation of the respective genes. Integrated analysis of hepatic RNA sequencing from these mice by FoxO1 and PPARα chromatin immunoprecipitation sequencing revealed a concerted regulation o

SUBMITTER: Kitamoto T 

PROVIDER: S-EPMC12451083 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature