Long-term outcomes of fertility-sparing treatment in endometrial carcinoma and endometrial intraepithelial neoplasia: Recurrence risk factors over a 9-year follow-up.

ABSTRACT:

Introduction

Fertility-sparing treatments using oral progestins have demonstrated promising oncologic outcomes for endometrial intraepithelial neoplasia and early-stage endometrial cancer. However, the high recurrence rate remains a major concern, and the literature on long-term follow-up outcomes is limited. This study aimed to identify recurrence risk factors by analyzing clinicopathological and molecular profiles in a cohort with a median follow-up of 9 years.

Material and methods

This retrospective study included patients under 45 years of age who were diagnosed with endometrial intraepithelial neoplasia or endometrial cancer and received fertility-sparing treatments at our center between 2010 and 2021. Patients who achieved complete responses were categorized according

SUBMITTER: Hsu YT 

PROVIDER: S-EPMC12451189 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature