First-trimester biomarkers of gestational diabetes mellitus: A scoping review.

ABSTRACT: Gestational diabetes mellitus (GDM) affects approximately 14% of pregnancies globally, with rising incidence depending on the diagnostic criteria used. In the UK, screening relies on risk factors at booking, followed by a diagnosis via an oral glucose tolerance test in the second trimester. This approach may lack sensitivity and has poor tolerability. Emerging evidence suggests that GDM pathophysiology begins in the first trimester, with biomarkers showing potential for early prediction. Identifying these could enable earlier risk stratification, improved diagnostic pathways, and better maternal-fetal outcomes. This scoping review maps the existing literature on first-trimester biomarkers of GDM to evaluate their clinical utility and integration into predictive models. A literature search

SUBMITTER: Swinburne M 

PROVIDER: S-EPMC12451201 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature