COVID-19 vaccination around the time of conception and risk of placenta-mediated adverse pregnancy outcomes.

ABSTRACT:

Introduction

Although numerous studies have documented no association between COVID-19 vaccination during pregnancy and maternal and fetal health outcomes, fewer studies have evaluated fetal health effects after COVID-19 vaccination around the time of conception and early pregnancy, a time when maternal exposures may affect early placentation and the subsequent risk of placenta-mediated adverse pregnancy outcomes.

Material and methods

We used province-wide databases in Ontario to conduct a population-based cohort study including all live and stillbirths ≥20 weeks' gestation with a last menstrual period (LMP) between April 1 and December 31, 2021. We deterministically linked birth registry data to the vaccine registry for all 80 253 eligible pregnancies; 31 209 (38.9%) receiv

SUBMITTER: Regan AK 

PROVIDER: S-EPMC12451205 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature