Long-term cardiovascular risk in women with hypertensive disorders of pregnancy: Insights from polygenic risk scores.

ABSTRACT:

Introduction

The association between preeclampsia (PE) and an elevated risk of cardiovascular disease (CVD) is well documented. Recent genome-wide association studies of PE have further highlighted their possible common genetic background. We investigated how the history of hypertensive disorders of pregnancy (HDP), including the PE phenotype, and normotensive pregnancy, combined with polygenic risk scores (PRSs) for PE (PE-PRS), high systolic blood pressure (SBP-PRS), coronary artery disease (CAD-PRS) or stroke (stroke-PRS), affects the risk for CVD.

Material and methods

The study was conducted in the FinnGen cohort of 213 942 Finnish women, including 8858 women with PE, 17916 women with any HDP, and 196 026 parous controls. PE women were included in the HDP phenotype. Part

SUBMITTER: Kivioja A 

PROVIDER: S-EPMC12451206 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature