Association of maternal asthma with congenital heart defects in offspring.

ABSTRACT:

Introduction

Asthma is the most common chronic disease among pregnant women. Some studies have linked maternal asthma to an increased risk of congenital malformations, particularly congenital heart defects (CHDs). Among these, ventricular septal defect (VSD) is the most common, accounting for nearly half of all CHD cases. We investigated the association between maternal asthma and the risk of CHD in offspring. As a sensitivity analysis, we also examined the associations between maternal atopic predisposition, maternal use of asthma medication, and CHD risk.

Material and methods

This retrospective, population-based study utilized a comprehensive birth cohort of all singleton births in Finland between 1996 and 2018. Data were derived by linking four high-coverage national heal

SUBMITTER: Kemppainen M 

PROVIDER: S-EPMC12451212 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature