Peutz-Jeghers syndrome in gynecological cancers: bibliometric trends, clinical insights, and future directions.

ABSTRACT:

Background

Peutz-Jeghers syndrome (PJS) is an autosomal dominant disorder caused by germline mutations in the STK11 tumor suppressor gene. It is characterized by mucocutaneous pigmentation, gastrointestinal polyposis, and a significantly elevated risk of various malignancies. While the association between PJS and gastrointestinal cancers is well established, its relationship with gynecological malignancies, particularly gastric-type endocervical adenocarcinoma (G-EAC), remains poorly understood. The rarity and clinical heterogeneity of PJS have hindered the development of evidence-based guidelines, especially for gynecological tumors.

Methods

We conducted a comprehensive bibliometric analysis of 96 English-language publications from 2010 to 2024 to map global research trends

SUBMITTER: Niu T 

PROVIDER: S-EPMC12451278 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature