Validation of fully automated intensity-modulated proton therapy with and without transmission beams for nasopharyngeal cancer.

ABSTRACT:

Background and purpose

Intensity-modulated proton therapy (IMPT) offers dose/volume advantages for nasopharyngeal cancer (NPC), however is complex, time-consuming, and the Bragg-peak's broad lateral penumbra can compromise target coverage near critical structures. Transmission proton beams (TBs) may mitigate this, while fully automated planning can ensure high-quality plans with reduced planning times. This study aimed to evaluate the added value of TBs in robust, fully automated IMPT (autoIMPT) planning for NPC, and benchmarking these against manually generated clinical IMPT plans.

Materials and methods

Twenty-four NPC patients previously treated with IMPT with 70.00 Gy(RBE) to the primary tumor and 54.25 Gy(RBE) to the elective volumes were included. AutoIMPT- and autoIMPT

SUBMITTER: Huiskes M 

PROVIDER: S-EPMC12451356 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature