Distinctive fish collagen drives vascular regeneration by polarizing macrophages to M2 phenotype via TNF-α/NF-κB pathway.

ABSTRACT: Collagen is a structural protein that plays a critical role in tissue regeneration and is widely utilized in biomedical applications. Recent studies have demonstrated that collagen can modulate macrophage polarization; however, most studies have focused on mammalian collagen such as type I collagen derived from bovine and pig sources. In this study, we performed a comprehensive investigation of the role of collagen derived from aquatic sources, specifically fish swim bladder-derived collagen (SCC), in modulating macrophage inflammation using in vitro and in vivo experiments. First, collagen-coated and collagen-incorporated electrospun poly(ε-caprolactone) (PCL) films were prepared. RNA-Seq analysis showed that SCC could promote M0 and M1 phenotype macrophage transition into M

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12451383 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature