Molecular Expression Differences in Specific Blood Mononuclear Cell-Types Identify Patients With AL Amyloidosis.

ABSTRACT: The diagnosis of AL amyloidosis is often challenging due to its systemic nature and heterogeneous clinical presentation. Current serological biomarkers for diagnosis and monitoring are not optimal. We have considered the possibility that mononuclear cell-type specific molecular expression can be used to develop blood-based biomarkers to diagnose and monitor patients with AL amyloidosis. Peripheral blood monocytes and CD4⁺ T cells from patients with documented AL amyloidosis or myeloma without amyloidosis were assessed by enhanced flow cytometric analysis for expression levels of 20 analytes chosen for the possibility that their expression levels may lead to diagnostic assays and biomarkers. We found definitive expression level differences for brain-derived neurotrophin factor (B

SUBMITTER: Kaplan D 

PROVIDER: S-EPMC12451396 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature