Reduced FGF9 Leads to Kidney Injury Through Regulating Renal Tubular Epithelial Cell EMT in Diabetes.

ABSTRACT: Diabetic nephropathy (DN) stands out as one of the most prevalent and severe chronic microvascular complications associated with diabetes, serving as the primary cause of end-stage renal disease (ESRD) in developed and developing countries. However, the precise pathogenesis remains incompletely elucidated. Our study suggests FGF9 as a key gene in DN using bioinformatics analysis. We found a negative correlation between FGF9 and serum creatinine and a positive one with glomerular filtration rate in DN patients. FGF9 expression was lower in DN patients' glomeruli and tubules. High FGFR expression in renal tubular cells, along with increased α-SMA and TGF-β1, indicates a role for the epithelial-to-mesenchymal transition (EMT) process in diabetes mellitus (DM) mouse renal tubular epithelial ce

SUBMITTER: Chen WQ 

PROVIDER: S-EPMC12451398 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature