Prenatal exposure to a mixture of per- and polyfluoroalkyl substances (PFAS) and lung function and immune-related outcomes among males in childhood and young adulthood.

ABSTRACT:

Background

Prenatal exposure to per- and polyfluoroalkyl substances (PFAS) may influence lung and immune system development, but previous epidemiological studies are inconclusive and have not extended into young adulthood.

Objective

To examine associations between prenatal exposure to a mixture of PFAS and respiratory and immune-related outcomes in a cohort of males.

Methods

We studied 866 males with maternal pregnancy plasma measured for 15 PFAS, triclosan, and 10 phthalate metabolites used as a proxy for prenatal exposure. Spirometry was measured at approximately age 19 years. Asthma in young adulthood was reported in questionnaires at age 18 years. Asthma, hay fever, and eczema at 7 and 11 years of age were based on parental reports. We estimated the difference in

SUBMITTER: Hull SD 

PROVIDER: S-EPMC12451454 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature