Synthesis, characterization, DNA interaction, and anticancer studies of novel <i>facial</i> tricarbonylrhenium(i) complexes with uracil-derived ligands.

ABSTRACT: Herein, we report the formation and characterisation of novel rhenium(i) complexes with bidentate uracil chelating ligands. Three metal complexes including fac-[Re(CO)₃(urda)Cl] (1) (urda = 5, 6-diamino-1, 3-dimethyluracil), fac-[Re(CO)₃(uramb)Br] (2) (uramb = amino-5-((2-aminobenzylidene)amino)-1,3-dimethyluracil) and fac-[Re(CO)₃(urqn)Br] (3) (urqn = amino-5-((isoquinolin-3-ylmethylene)amino)-1,3-dimethyluracil) were spectroscopically characterized. Structural elucidations were corroborated by single-crystal X-ray crystallography, TOF mass spectrometry, and elemental analysis. These metal complexes retain their structural integrity in aqueous media during UV-Vis spectrophotometric titrations. Anticancer screening of the metal complexe

SUBMITTER: Abdullah S 

PROVIDER: S-EPMC12451525 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature