Non-antifungal medications administered during fungal infections drive drug tolerance and resistance in <i>Candida albicans</i>.

ABSTRACT: Introduction. Fungal infections are increasingly concerning, particularly in immunocompromised patients. These patients often suffer from comorbidities and receive multiple, non-antifungal medications.Gap Statement. The effects of these co-administered medications on fungal cells - and their potential to influence antifungal drug efficacy - are poorly understood.Aim. This study investigates non-antifungal medications commonly administered in parallel to antifungals and evaluates their impact on fungal susceptibility.Methodology. We systematically reviewed clinical guidelines to identify non-antifungal medications frequently co-prescribed with antifungals. Focusing on Candida albicans, the most prevalent fungal pathogen, we examined whether the presence of

SUBMITTER: Obermeier M 

PROVIDER: S-EPMC12451754 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature