Variation in facility-level likelihood of drug-resistant <i>Staphylococcus aureus</i> in outpatients remains after patient-level risk adjustment.

ABSTRACT:

Objective

Effective empiric therapy options for Staphylococcus aureus infections are limited by rising rates of resistance to non-beta lactam antimicrobial agents. The use of cumulative susceptibility testing results, antibiograms, are promoted as a tool for improving empiric therapy decisions, but it is unclear how much of the variation in antibiograms between facilities and the associated efficacy of antimicrobial agents is driven by underlying differences in patient characteristics such as comorbidities and prior antibiotic exposure.

Design

Retrospective cohort study of 46,866 S. aureus specimens from outpatient settings of the Veterans Health Administration (VHA) from 2021 and 2022 linked to electronic health record information on patient comorbidities, pri

SUBMITTER: Carrel M 

PROVIDER: S-EPMC12451804 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature