Safety and efficacy of antimicrobial optimization based on negative results from BioFire FilmArray Pneumonia panel and respiratory culture.

ABSTRACT:

Background

The BioFire FilmArray Pneumonia (BFP) panel is a multiplexed nucleic acid test intended to detect respiratory pathogens from sputum or bronchoalveolar lavage (BAL) specimens. Efficacy and safety of de-escalation strategies in patients with negative BFP results remain unclear.

Methods

This was a multicenter, retrospective analysis of patients with suspected pneumonia and negative BFP and respiratory cultures. Patients were stratified into two groups: those whose antibiotic therapy was discontinued or withheld within 48 hours of a negative BFP (ATDW group) and those whose antibiotic therapy was continued (ATC group). We evaluated composite primary outcome of in-hospital mortality and 30-day readmission due to pneumonia (PNA) or recurrent PNA during index admission a

SUBMITTER: Yoo N 

PROVIDER: S-EPMC12451807 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature