Individual Differences in Developmental Trajectories of Global and Subcortical Brain Volumes Between Late Childhood and Late Adolescence: Findings From a 12-Wave Neuroimaging Study.

ABSTRACT: Adolescence is characterised by protracted structural brain development, with different brain regions showing distinct developmental trajectories. While studies have identified average developmental trajectories, few have formally quantified individual differences in the developmental trajectories of global brain structures and subcortical regions across adolescence. Utilising the unique 12 waves of high temporal resolution MRI data from the Danish HUBU cohort (N = 90; ages seven to 21; 745 scans; on average 8.30 scans per participant) and nonlinear mixed modelling techniques, we examined both group and individual-level patterns of volumetric change in global brain measures and subcortical regions. At the group level, cortical grey matter, total brain, caudate, putamen, accumbens, and thal

SUBMITTER: Carrick C 

PROVIDER: S-EPMC12451839 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature