Plasma Metabolome, Long-term Body Weight Change, and Type 2 Diabetes in U.S. Individuals.

ABSTRACT:

Objective

Body weight influences the blood metabolome, but whether specific plasma metabolomic profiles predict long-term weight change remains unclear. We aimed to investigate associations among plasma metabolites, current weight, weight change trajectories, and incident type 2 diabetes (T2D) in adults.

Research design and methods

We profiled 260 plasma metabolites in 7,499 U.S. health professionals. A metabolomic score predicting BMI change over time was derived using elastic net regression with a training/testing approach. Associations with incident T2D were examined using multivariable Cox models.

Results

Metabolomic predictors of BMI change varied by baseline weight status. In lean individuals, 46 metabolites significantly predicted BMI change slope compared with

SUBMITTER: Wu Z 

PROVIDER: S-EPMC12451841 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature