General Approach To Access Aldehyde Oxidase Metabolites of Drug Molecules via <i>N-</i>Oxidation/Reissert-Henze-Type Reaction.

ABSTRACT: Aldehyde oxidase (AO) contributes significantly to metabolism of drug molecules containing heteroaromatics, and the lack of synthetic mimics for AO-mediated reactivity is a barrier to drug development. Herein, we use tandem N-oxidation and Reissert-Henze-type reaction of quinoline and related heteroaromatics to form quinolone derivatives. This reactivity is showcased with small molecule building blocks and active pharmaceutical ingredients with known AO metabolism. The products of the latter substrates map directly onto established AO metabolites.

SUBMITTER: Hanneman CM 

PROVIDER: S-EPMC12451861 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature