Effect of electronic drug-drug interaction alerts on patient and clinician outcomes: a systematic review.

ABSTRACT:

Objectives

Drug interaction checking software is ubiquitous in clinical decision support systems (CDSS-DI) but patient relevance and accuracy are variable and the impact on patient outcomes is unproven. We compared the effectiveness of CDSS-DI with similar care without CDSS-DI.

Materials and methods

We searched multiple bibliographic databases from 1990 to end-2024 for randomized trials (RCTs) or prospective cohort studies evaluating CDSS-DI at prescription, dispensing, or administration compared to a control group, and assessing clinical, process and burden outcomes. We used Cochrane Risk of Bias v2.0 and ROBINS-I to assess risk of bias and random effects modeling using meta 6.0 package in R for meta-analysis.

Results

Eight studies were included-7 RCTs (2 parallel an

SUBMITTER: Holbrook AM 

PROVIDER: S-EPMC12451929 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature