Oral microbial signatures underlying recurrence via PI3K/AKT/mTOR pathway modulation in oral squamous cell carcinoma.

ABSTRACT:

Background

Oral squamous cell carcinoma (OSCC) often recurs locally, reducing survival. The oral microbiome may influence tumor recurrence, but its prognostic role is unclear. This study investigated oral microbiomes associated with OSCC recurrence and their prognostic merit.

Materials and methods

Saliva samples were collected from 133 patients with OSCC. 16S rRNA gene sequencing was performed, and microbial signatures were predicted via XGBoost. Functional metagenomic prediction was conducted using PICRUSt2.

Results

XGBoost identified Eubacterium, Lactobacillus, Kingella, Paludibacter, Parvimonas, Staphylococcus, and Veillonella as predictive for OSCC recurrence. Eubacterium and Lactobacillus were signifi

SUBMITTER: Kwack DW 

PROVIDER: S-EPMC12451969 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature