Manganese (III) tetrakis (4-benzoic acid) porphyrin (MnTBAP) represses sulfide:quinone oxidoreductase expression and targets the sulfido-redox system in glioblastoma models.

ABSTRACT:

Background

The adaptation of the redox system and bioenergetics is a major factor contributing to cancer metabolism. Redox therapy is promising but still requires molecular studies that consider the reactive species interactome (RSI) concept, which integrates reactive oxygen, nitrogen, sulfur, carbonyl species, and redox enzymes. Our aim was to decipher the role of the RSI in glioblastoma (GBM), including by challenging the RSI with the MnTBAP redox agent.

Methods

The effects of MnTBAP on the redox system and bioenergetics were investigated on several GBM models, namely in vitro 2D culture, in vitro 3D culture with two human GBM tumoroids, and in vivo preclinical model, which included male and female comparisons.

Results

We show - for the first ti

SUBMITTER: Malard E 

PROVIDER: S-EPMC12451972 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature