Light responsive hydrogen selenide (H<sub>2</sub>Se)/hydrogen diselenide (H<sub>2</sub>Se<sub>2</sub>) donors: applied for protein <i>S</i>-selenylation on PRDX6.
Ontology highlight
ABSTRACT: Hydrogen selenide (H2Se) is an important metabolite in selenium biochemistry and plays a crucial role in redox biology. While its significance has become increasingly recognized, research on H2Se is challenging due to its instability and high reactivity. Suitable compounds (aka donors) that can selectively produce H2Se in biological systems would facilitate this research field. In this work, we explored photo-triggered H2Se donors by utilizing two structural templates: 2-nitrobenzyl selenides and 2-methoxy-6-naphthacyl selenides. The photoreactions of these compounds under light were studied. 2-Nitrobenzyl selenides were found to release H2Se (and its oxidized form H2Se2) slowly under UV light, but the released H<
SUBMITTER: Roy B
PROVIDER: S-EPMC12452010 | biostudies-literature | 2025 Oct
REPOSITORIES: biostudies-literature
ACCESS DATA
