Colla Corii Asini regulate collagen regeneration in UV exposure-induced skin photoaging in mice.

ABSTRACT:

Background

Ultraviolet (UV) radiation is the primary external factor driving skin aging, mainly due to imbalanced collagen synthesis and degradation. Identifying new drugs targeting collagen regeneration may effectively delay skin aging. Colla Corii Asini (CCA), derived from donkey skin, contains abundant proteins and peptides, suggesting potential benefits against photoaging through collagen homeostasis regulation. However, its mechanisms and active components remain unclear.

Objective

This study aimed to evaluate whether CCA mitigates photoaging by regulating collagen synthesis and degradation, identifying its active components and molecular targets to support future pharmacological studies.

Methods

A photoaging mouse model was established, and the therapeutic effec

SUBMITTER: Ma Y 

PROVIDER: S-EPMC12452026 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature