Balancing benefit and burden: treatment intensification in paediatric KMT2A rearrangements acute myeloid leukaemia.

ABSTRACT:

Background and purpose

Chromosomal rearrangements involving KMT2A (KMT2A-r) occur in 20% of paediatric acute myeloid leukaemia (AML). Previous studies reported that the outcome depends on the specific fusion partner. The study aimed to report the outcomes of paediatric KMT2A-r AML patients and to assess the impact of different fusion partners. Patient/material and methods: We retrospectively analysed 610 paediatric patients with intermediate-risk (IR) AML diagnosed at Children's Cancer Hospital Egypt, from January 2008 to December 2021. Patients were assigned to four groups based on fusion partner.

Results

Of 610 patients diagnosed with IR-AML, 150 (24.6%) had KMT2A rearrangements. KMT2A-r was significantly associated with hyperleukocytosis (P = 0.029), central nervous syste

SUBMITTER: Fayez H 

PROVIDER: S-EPMC12452033 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature