Impact of radiation dose on neurocognitive function and quality of life in long-term survivors of childhood brain tumour.

ABSTRACT:

Background and purpose

Children treated with radiotherapy (RT) for a brain tumour often exhibit neurocognitive impairment and report lower quality of life (QoL) later in life. The aim of this nationwide cross-sectional cohort study was to explore the impact of RT dose to brain organs at risk (OARs) on neurocognition and QoL in long-term survivors of childhood brain tumours. Patient/material and methods: A total of 132 survivors of childhood brain tumours, diagnosed from 2001 to 2017 in Denmark, underwent neurocognitive tests and QoL questionnaires at least 5-years post-diagnosis. Neurocognitive assessments were complete and available for 86 patients (61 no-RT/25 RT), and QoL scores for 107 (79 no-RT/28 RT). Mann Whitney U-tests were used to compare scores between no-RT and RT group

SUBMITTER: Toussaint L 

PROVIDER: S-EPMC12452035 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature