A functional comparison of two transplantable syngeneic mouse models of melanoma: B16F0 and YUMM1.7.

ABSTRACT: The B16 murine melanoma cell lines are considered the gold standard for testing melanoma immunotherapies due to low treatment success rates. However, the clinical relevance of these models has been questioned due to a mutational landscape void of driver mutations typically seen in human melanomas and a tendency to form necrotic cores at high tumor volumes. Creating the YUMM1.7 line addressed these limitations by providing an additional contextually consistent model with a more clinically relevant genetic background. The combined use of both models can generate stronger studies in melanoma immunology and immunotherapy. However, to date, there have been no direct functional comparisons of the characteristics of these two models to inform the design of such studies. To address this, we conduc

SUBMITTER: Klinke DJ 

PROVIDER: S-EPMC12452060 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature