Inhibition of ATG7 promotes orthodontic tooth movement by regulating the RANKL/OPG ratio under compression force.

ABSTRACT:

Objective

Autophagy serves as a protective mechanism in response to mechanical stress during OTM. However, the role of ATG7, a key regulatory gene in autophagy, in modulating periodontium remodeling during OTM remains unclear. This study aims to investigate the potential modulation of periodontium remodeling by ATG7 under compression force.

Materials and methods

HPDLSCs and a rat OTM model were used as in vitro and in vivo systems to study the effect of compressive stress on autophagy and osteoclast-related markers. To investigate the role of ATG7, hPDLSCs with ATG7 knockdown and ATG7^+/- rats were used in this study.

Results

Compression force activates autophagy and increases the RANKL/OPG ratio. ATG7 knockdown significantly suppresses autopha

SUBMITTER: Yang Z 

PROVIDER: S-EPMC12452073 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature