Blood memory CD8 T cell phenotypes in lung cancer patients predict immune checkpoint treatment responses.

ABSTRACT:

Background

Immune checkpoint inhibition (ICI) has become a standard treatment to re-invigorate tumor-attacking T cell responses in multiple cancer indications, yet a patient's response is unpredictable even with a confirmed expression of the relevant targets such as PD-1 or PD-L1. Previously identified biomarkers of response have relatively low accuracy, making it difficult to reliably employ them as predictors of clinical response.

Methods

We comprehensively phenotyped peripheral blood CD8+ T cells from patients with non-small cell lung cancer by analyzing surface marker expression, transcriptome, and TCR repertoire with single-cell sequencing technology. The cohorts were comprised of patients who (a) responded to anti-PD(L)1 treatment for a prolonged period of time (b) wer

SUBMITTER: Schmidt F 

PROVIDER: S-EPMC12452098 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature