Genomic and phylogenetic analysis of hypervirulent <i>Klebsiella pneumoniae</i> ST23 in Ireland.

ABSTRACT: Hypervirulent Klebsiella pneumoniae (hvKp) has emerged as a pathogen of global concern associated with invasive community-acquired infections. The combination of hypervirulence and carbapenem resistance can result in severe and difficult-to-treat infections. This retrospective study aimed to investigate the spread of hvKp sequence type 23 (ST23) in Ireland and the convergence of hypervirulent (hv) and antimicrobial resistance genotypes. Short-read sequences (PE300) for 90 K. pneumoniae ST23 isolates were generated by the Galway Reference Laboratory Services (GRLS). Isolates were from screening swabs (n=59), invasive infections (n=18), non-invasive sites (n=12) and the hospital environment (n=1). The virulence and resistance content we

SUBMITTER: Maguire M 

PROVIDER: S-EPMC12452180 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature