Healthcare-related transmission of mobile genetic elements co-carrying <i>bla</i> _NDM and 16S rRNA methyltransferase genes in multiple <i>Enterobacterales</i>.

ABSTRACT: Aminoglycosides are used in the treatment of serious infections with Gram-negative bacteria, especially those resistant to beta-lactams and carbapenems. 16S rRNA methyltransferases (16S-RMTase) are capable of conferring resistance to nearly all aminoglycosides. They are sometimes detected in combination with bla _NDM. This study describes the mobile genetic elements associated with bla _NDM and 16S-RMTase (co-)carriage in Enterobacterales from Ireland in the period 2019-2023. All isolates (n=58) carrying both bla _NDM and a 16S-RMTase gene between 2019 and 2023 were obtained from the CPE National Reference Laboratory Service. Short-read sequences were generated for all isolates, and long-read sequences were generated for a su

SUBMITTER: Maguire M 

PROVIDER: S-EPMC12452189 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature