Capicua Refines Mossy Fiber-CA3 Axon Targeting in the Late Postnatal Hippocampus.

ABSTRACT: Proper brain wiring relies on the precise distribution of axonal projections to specific subcellular domains of their target neurons. These spatially confined connections establish the anatomical foundation for neural circuit assembly. The mossy fiber (MF)-CA3 pathway in the hippocampus is an excellent system to study the mechanisms underlying lamina-specific connectivity. In rodents, MF projections develop postnatally and reach their mature configuration by the end of the second postnatal week. MF axons synapse on the proximal segments of the dendrites but avoid the somas of CA3 pyramidal neurons. As dentate gyrus granule neurons are continuously generated and integrated into the existing hippocampal circuit throughout the postnatal period and adulthood, the mechanisms that guide MF axons

SUBMITTER: van Bruggen R 

PROVIDER: S-EPMC12452221 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature