Ionic surfactants alter virus surface properties and electrostatic interactions in aqueous systems.

ABSTRACT: Interactions between viruses and sub-inhibitory concentrations of surfactants in water systems are understudied. At concentrations below the minimum inhibitory concentration (MIC), surfactants may interact with virus surface proteins without virus inactivation and alter virus surface properties. This study determined the MIC of benzyldimethyldodecylammonium chloride (BAC) and sodium dodecyl sulfate (SDS) on human adenovirus (ADV, non-enveloped, dsDNA) and mouse hepatitis virus (MHV, enveloped, ssRNA), and how sub-MIC surfactants influence virus isoelectric point (IEP), hydrated diameter, and interact with virus surface proteins. Both surfactants had MICs of 1 mg/L over 60 minutes. Experimental IEPs were lower than IEPs estimated based on amino acid structures. The ADV IEP was 3.8 without s

SUBMITTER: Loey M 

PROVIDER: S-EPMC12452283 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature